Insomnia is defined as a combination of both dissatisfaction with sleep and a significant negative impact on daytime functioning. Insomnia is, worldwide, the most commonly reported sleeping disorder.

High blood pressure (also known as hypertension) is one of the most common medical conditions and its prevalence continues to rise. If someone’s high blood pressure can’t be lowered despite treatment with a combination of three anti-hypertensive drugs of different categories (including a diuretic), they may have resistant hypertension.

Fabry disease is a rare inherited disorder in which a particular lipid (a fat-like substance) can’t be broken down by the body, leading to its build-up in the cells of the body organs.